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  Link Between Brain’s Memory Center and Heart Function

Neuroscience NewsNeuroscience News
<https://neurosciencenews.com/author/neurosciencenew/>//November 8, 2017
Featured
<https://neurosciencenews.com/neuroscience-topics/featured/>Neurology
<https://neurosciencenews.com/neuroscience-topics/neurology/>Neuroscience <https://neurosciencenews.com/neuroscience-topics/neuroscience/>4
min read
<https://neurosciencenews.com/alzheimers-heart-function-memory-7906/>

/Summary: Vanderbilt researchers report elderly people whose hearts pump
less blood have reduced blood flow in the temporal lobe. Previous
studies report the temporal lobe is a critical brain area for the
development of Alzheimer’s disease./

/Source: Vanderbilt University./

*Research by a team of Vanderbilt University Medical Center (VUMC)
scientists suggests that older people whose hearts pump less blood have
blood flow reductions in the temporal lobe regions of the brain, where
Alzheimer’s pathology first begins.*

The brain, which accounts for only 2 percent of total body weight,
typically receives 12 percent of blood flow from the heart — a level
maintained by complex, automatic processes, which maintain consistent
blood flow to the brain at all times.

Angela Jefferson, Ph.D., director of the Vanderbilt Memory and
Alzheimer’s Center, and colleagues investigated whether lower cardiac
index (the amount of blood flowing out of the heart adjusted for body
size) correlated with lower blood flow to the brain.

The purpose of the study was to better understand whether reductions in
brain blood flow might explain clinical observations in prior research
that have linked heart function to cognitive impairment, Alzheimer’s
disease and dementia.

“We currently know a lot about how to prevent and medically manage many
forms of heart disease, but we do not yet know how to prevent or treat
Alzheimer’s disease,” Jefferson said.

“This research is especially important because it may help us leverage
our knowledge about managing heart health to address and treat risk
factors for memory loss in older adults before cognitive symptoms develop.”

The study, published online in /Neurology/ Nov. 8, involved 314
Vanderbilt Memory and Aging Project participants with an average age of
73. Thirty-nine percent had mild cognitive impairment, a condition that
increases the risk of developing Alzheimer’s disease or dementia, while
the remaining participants had normal cognitive function.

Cardiac index was measured with echocardiography, and blood flow in the
brain was measured with magnetic resonance imaging (MRI).

The magnitude of the association between lower cardiac index and lower
cerebral blood flow in the temporal lobe, a brain region critical for
memory processing, was estimated to correspond to 15 to 20 years of
advancing age.

“One way to put these results into a meaningful context is to define how
one year of aging relates to blood flow in the brain,” Jefferson said.
“Then, we compare the effect of one year of aging to the effect of lower
cardiac index. When we do that, we find that the effect of cardiac index
on blood flow in the temporal lobes corresponds to 15 to 20 years of age.”

Image shows the location of the temporal lobe.
<https://i1.wp.com/neurosciencenews.com/files/2017/11/temporal-lobe-blood-flow-neurosciencenews.jpg>

The magnitude of the association between lower cardiac index and lower
cerebral blood flow in the temporal lobe, a brain region critical for
memory processing, was estimated to correspond to 15 to 20 years of
advancing age. NeuroscienceNews.com image is credited to Anatomography.

The individuals who participated in the research are part of a
longitudinal study that will continue to track their health and
cognitive abilities.

The study raises questions about whether autoregulation of blood flow in
the brain is less effective as people age, Jefferson said, as well as
the greater role that vascular health may play in exacerbating
Alzheimer’s pathology or clinical symptoms of dementia.

“It is now clear from a growing body of research evidence that there is
a strong connection between heart health and brain health,” said Maria
Carrillo, Ph.D., chief science officer of the Alzheimer’s Association,
which helped fund the study.

“We are pleased to have provided the initial seed funding for this
intriguing science that is beginning to identify and investigate the
mechanisms behind that connection. Those mechanisms, once confirmed, may
hold the key to effective treatments and prevention strategies for
Alzheimer’s disease and other dementias.”

Jefferson is the lead author of the study with 13 Vanderbilt colleagues
as co-authors from neurology, radiology and radiological sciences,
cardiovascular medicine, geriatrics and biostatistics.

About this neuroscience research article

*Funding:* The study was funded by the Alzheimer’s Association, the
National Institute on Aging, National Institute of Neurological
Disorders and Stroke, American Heart Association, Paul B. Beeson Career
Development Award in Aging, Vanderbilt Clinical Translational Science
Award and the Vanderbilt Memory and Alzheimer’s Center.

*Source:* Tom Wilemon – Vanderbilt University <https://news.vanderbilt.edu/>
*Publisher:* Organized by NeuroscienceNews.com.
<https://neurosciencenews.com/alzheimers-heart-function-memory-7906>
*Image Source:* NeuroscienceNews.com image
<https://commons.wikimedia.org/wiki/File:Temporal_lobe_-_lateral_view.png>
is credited to Anatomography, licensedCC BY-SA 2.1 JP.
<https://creativecommons.org/licenses/by-sa/2.1/jp/deed.en>
*Original Research:* The study will appear in /Neurology/.

Cite This NeuroscienceNews.com Article

  * MLA <#>
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  * Chicago <#>

Vanderbilt University “Link Between Brain’s Memory Center and Heart
Function.” NeuroscienceNews. NeuroscienceNews, 8 November 2017.
<http://neurosciencenews.com/alzheimers-heart-function-memory-7906/>.
Vanderbilt University (2017, November 8). Link Between Brain’s Memory
Center and Heart Function. /NeuroscienceNews/. Retrieved November 8,
2017 from http://neurosciencenews.com/alzheimers-heart-function-memory-7906/
Vanderbilt University “Link Between Brain’s Memory Center and Heart
Function.”
http://neurosciencenews.com/alzheimers-heart-function-memory-7906/
(accessed November 8, 2017).
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Alzheimer's disease
<https://neurosciencenews.com/neuroscience-terms/alzheimers-disease/>anatomy
<https://neurosciencenews.com/neuroscience-terms/anatomy/>biology
<https://neurosciencenews.com/neuroscience-terms/biology/>blood flow
<https://neurosciencenews.com/neuroscience-terms/blood-flow/>cognitive
function
<https://neurosciencenews.com/neuroscience-terms/cognitive-function/>heart
function
<https://neurosciencenews.com/neuroscience-terms/heart-function/>Memory
<https://neurosciencenews.com/neuroscience-terms/memory/>neurobiology
<https://neurosciencenews.com/neuroscience-terms/neurobiology/>neurodegeneraitve
diseases
<https://neurosciencenews.com/neuroscience-terms/neurodegeneraitve-diseases/>Neurology
<https://neurosciencenews.com/neuroscience-terms/neurology/>Neuroscience
<https://neurosciencenews.com/neuroscience-terms/neuroscience/>temporal
lobe
<https://neurosciencenews.com/neuroscience-terms/temporal-lobe/>Vanderbilt
University
<https://neurosciencenews.com/neuroscience-terms/vanderbilt-university/>

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