While paradigms may seem very solid they are only constructs created by us as we observe patterns and what seems to be. They can be helpful in some ways and limit in other ways. To create new Paradigm means we need to be open to a new pattern of looking at things. This article talks about random damage, normal aging, and cellular aging and the interest in a factor called homeostatic imbalance or allostatic load. This is the way the body deals with incoming stress and how long it takes to recover from the influence.   

The glymphatic pathway is a system which facilitates continuous cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange and plays a key role in removing waste products from the rodent brain. Dysfunction of the glymphatic pathway may be implicated in the pathophysiology of Alzheimer's disease. Intriguingly, the glymphatic system is most active during deep wave sleep general anesthesia. By using paramagnetic tracers administered into CSF of rodents, we previously showed the utility of MRI in characterizing a macroscopic whole brain view of glymphatic transport but we have yet to define and visualize the specific flow patterns. Here we have applied an alternative mathematical analysis approach to a dynamic time series of MRI images acquired every 4 min over ∼3 hrs in anesthetized rats, following administration of a small molecular weight paramagnetic tracer into the CSF reservoir of the cisterna magna. We use Optimal Mass Transport (OMT) to model the glymphatic flow vector field, and then analyze the flow to find the network of CSF-ISF flow channels. We use 3D visualization computational tools to visualize the OMT defined network of CSF-ISF flow channels in relation to anatomical and vascular key landmarks from the live rodent brain. The resulting OMT model of the glymphatic transport network agrees largely with the current understanding of the glymphatic transport patterns defined by dynamic contrast-enhanced MRI revealing key CSF transport pathways along the ventral surface of the brain with a trajectory towards the pineal gland, cerebellum, hypothalamus and olfactory bulb. In addition, the OMT analysis also revealed some interesting previously unnoticed behaviors regarding CSF transport involving parenchymal streamlines moving from ventral reservoirs towards the surface of the brain, olfactory bulb and large central veins.

Having a fully functioning lymphatic system is critical for your overall health and ability to fight cancer. Yet so few people are knowledgeable about the lymphatic system. What’s even more concerning is that only a small percentage of health care practitioners ever discuss lymph health with their patients.

This article discusses 4 ways to keep your lymphatic system healthy.

Michael Morgan talks about four simple steps to preventing Alzheimer’s disease. Research is giving us more and more reason to hope that Alzheimer’s is not only preventable but quite possibly reversible.

This article pertains to the alternative therapies and remedies being used to alleviate aches and pains, stress, and treat seasonal allergies.

Slow breathing practices have been adopted in the modern world across the globe due to their claimed heath benefits.This has interest in researchers and clinicians who decided to investigate into the effects of slow breathing. This is an overview of normal respiratory phisiology to research in healthy humans.

This article is about a major breakthrough that researchers show it possible to make dopamine cells from astrocytes, accelerating traditional stem cell procedures and improving disease symptoms.  

Physical touch is the foundational element of human development and culture. The growing preoccupation with digital media versus personal physical contact, combined with the social and legal media versus personal contact in our schools and workplaces, may unintentionally affect these factors negatively. To foster a safe social environment in a climate of mediated communication, we should intentionally hold onto physical touch.   

This is a research article about nerve injury in humans that often results in persistent or chronic neuropathic pain which is characterized by spontaneous burning pain accompanied by hyperalgesia and allodynia.

These findings may improve the knowledge about the involvement of astrocytes, microglia, and BDNF in the chronic pain and show that NM treatment which alleviates neuropathic pain, affects glial cells and BDNF expression.